Recently, the subject of "Recovery Research on Melamine-Cyanuric Acid Combined Toxicity and Renal Injury" undertaken by the Heilongjiang Provincial Center for Disease Control has passed the acceptance of experts organized by the Science and Technology Department of Heilongjiang Province. The study found that after stopping the intake of melamine, the body can gradually form new renal tubules within a certain period of time, prompting the return of normal renal function.
The "milk powder incident" that occurred in 2008 has long since subsided, and the problem of illegally adding melamine to food has been effectively controlled, but the academic community has always been difficult to assess the prognosis of renal pathological damage caused by melamine ingestion. Restorative scientific data on the combined toxicity of melamine and cyanuric acid and renal injury.
As one of the pioneers of melamine toxicity research, Wang Yuyan, the chief physician of the Heilongjiang Provincial Center for Disease Control, with the support of the Heilongjiang Natural Science Foundation, guided the research team to conduct an in-depth study on the recovery process of melamine-induced kidney damage in rats.
The study found that after oral ingestion of melamine, after the formation of crystals in the renal tubules and kidney damage, stop ingestion of melamine without drug intervention, the crystals in the renal tubules can be gradually discharged with urine. The crystals gradually decrease, the blood supply is improved, and the functions of filtration and concentration of the renal tubules also improve accordingly. At the same time, the renal tubular epithelial cells generated by the differentiation of interstitial cells begin to gradually form new renal tubules, so that the renal function gradually returns to normal .
In the rat model toxicity experiment, the research team has confirmed for the first time at home and abroad that melamine taken by mouth alone can produce crystals in the kidneys of animals, and the crystals formed by the joint exposure with melamine-melamine The structure between the two is basically the same, and the nature of the kidney disease is also the same. The in vitro melamine-cyanuric acid reaction heat test results confirmed that when melamine-cyanuric acid reacted to form crystals, it could release 75kJ / mol of heat. Based on this, the research group believes that these two chemical substances will exotherm instantly in the crystallization reaction of the renal tubules, which may cause secondary damage such as renal tubular epithelial degeneration, necrosis, and inflammatory cell infiltration.
The evaluation of industry experts pointed out that the above results filled many research gaps in the field at home and abroad, and provided a scientific basis for the melamine food safety risk assessment and the rehabilitation and follow-up treatment of clinical children.
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