Jo-Ann M. Jablonski, Andrew J. Aubin, and Wendy Harrop
Waters Corporation (Milford, MA, USA)
**Application Advantage**
The Prep 150 LC system is a cost-effective and highly reliable preparative chromatography solution ideal for isolating compounds from natural product extracts. Designed with simplicity in mind, it offers an intuitive workflow that streamlines the purification process.
Equipped with ChromScopeâ„¢ software, the Prep 150 LC system delivers an easy-to-use interface that enables users to quickly set up and execute separations, reducing training time and improving overall efficiency. This user-friendly approach ensures that even those new to preparative chromatography can achieve consistent results.
The system’s straightforward design and seamless integration of hardware and software make it an excellent choice for laboratories looking to boost productivity while maintaining high-quality separation performance.
**Waters Solutions**
- Prep 150 LC System
- ChromScopeâ„¢ Software
- Atlantis® T3 Prep OBD Column
- Atlantis T3 Analytical Column
**Key Words**
Separation, purification, preparative chromatography, Prep 150 LC, Echinacea, natural product, extract, ChromScope, cichoric acid
**Introduction**
Echinacea, commonly known as purple coneflower, is a hardy perennial plant belonging to the Compositae family. It thrives in dry climates and has been widely studied for its medicinal properties. One of the key bioactive compounds found in Echinacea is cichoric acid, a phenylpropanoid derivative with strong antioxidant and anti-inflammatory effects.
Recent research highlights the growing interest in cichoric acid, with over 50% of published studies focusing on its therapeutic applications, including treatment of upper respiratory infections, cancer support, and immune system enhancement. However, the concentration of cichoric acid in Echinacea extracts can vary significantly depending on factors such as geographic origin, growing conditions, and sample preparation methods.
To conduct further research, it is often necessary to isolate large quantities of the target compound through multiple injections of crude mixtures. In this application note, we demonstrate how the Prep 150 LC system, controlled by ChromScopeâ„¢ software, provides an efficient and reliable method for separating cichoric acid from Echinacea extracts. The principles described here are also applicable to other compounds with ultraviolet absorbance.
For a complete overview of the methodology and results, please download the full document:
**Separation of natural products from Echinacea extract using the Prep 150 LC system.doc**
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